Over the years, literally thousands of people have converged on the Cat's Meow to enjoy some of the cultural and musical activities that the club has to offer, and is a contributing part of what makes Las Vegas one of the most energetic cities in the world. Also, many celebrities have enjoyed some of the nightlife at the Cat's Meow. Artists ranging from
Soul singer Seal to country musicians Brooks and Dunn, comedian/songwriter "Weird Al" Yankovic, Smashing Pumpkins, Depeche Mode, and N'Sync have all visited the Cat's Meow, as well as Bill Gates of Microsoft, actors Tori Spelling, Mario Lopez, Julie and Doria of Playboy's Night Calls, and adult film star Stormy Daniels have stopped in to sing.
Aside from the more famous people that have visited Cat's Meow, several national television shows shot on-site broadcasts from the club. The festive atmosphere of the Cat's Meow has provided wonderful backdrop and ambiance for such popular TV programs like "The Regis and Kelly Show", MTV's "Road Rules" and "The Grind".