Over the years, literally thousands of people have converged on the Cats Meow to enjoy some of the cultural and musical activities that the club has to offer, and is a contributing part of what makes New Orleans one of the most energetic cities in the world. Also, many celebrities have enjoyed some of the nightlife at the Cats Meow. Artists ranging from
Soul singer Seal to country musicians Brooks and Dunn, comedian/songwriter "Weird Al" Yankovic, Smashing Pumpkins, Depeche Mode, and N'Sync have all visited the Cats Meow, as well as Bill Gates of Microsoft, actors Tori Spelling as well as Mario Lopez.
Aside from the more famous people that have visited Cats Meow, several national television shows shot on-site broadcasts from the club. The festive atmosphere of the Cats Meow has provided wonderful backdrop and ambiance for such popular TV programs like "The Regis and Kelly Show", MTV's "Road Rules" and "The Grind".